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Fluoroquinolones mode of action
 
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This antibiotic video explains the mode of action by fluoroquinolone antibiotics and their use in different bacterial infection. For more information, log on to- http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-materials.html
Views: 18011 Shomu's Biology
Fluoroquinolones: Mechanisms of Action and Resistance
 
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Developed and produced by http://www.MechanismsinMedicine.com Animation Description: In this animation, we demonstrate the biology of DNA replication leading to bacterial cell division in a gram positive bacterium, such as S. pneumoniae. The DNA is shown as a circular double strand within the bacterial cell. Like the DNA of all living organisms, it contains the unique genetic code for all of the proteins required for bacterial survival. Bacteria replicate by a process known as binary fission whereby one bacterium separates into 2 new daughter cells. However, before this can occur, the bacterium must make an identical copy of its complete circular DNA. DNA replication requires that the two strands of DNA separate so that the genetic code of the bacterium can be read and a new complimentary strand can be created for each of the original strands. To accomplish this, various enzymes known as helicases break the hydrogen bonds between the bases in the two DNA strands, unwind the strands from each other, and stabilize the exposed single strands, preventing them from joining back together. The points at which the two strands of DNA separate to allow replication of DNA are known as replication forks. The enzymes DNA polymerase then move along each strand of DNA, behind each replication fork synthesizing new DNA strands (in red) complementary to the original ones. As the replication forks move forward, positive superhelical twists in the DNA begin to accumulate ahead of them. In order for DNA replication to continue, these superhelical twists must be removed. The bacterial enzyme, DNA gyrase, which is also known as topoisomerase II, is responsible for removing the positive superhelical twists so that DNA replications can procede. DNA gyrase is an essential bacterial enzyme composed of two A and two B subunits which are products of the gyrA and gyrB genes. This enzyme has other important functions which affect the initiation of DNA replication and transcription of many genes. With the combined involvement of these enzymes, an entire duplicate copy of the bacterial genome is produced as the 2 replication forks move in opposite directions around the circular DNA genome. Eventually, as the 2 replication forks meet, 2 new complete chromosomes have been made, each consisting of 1 old and 1 new strand of DNA. This is referred to as semi-conservative replication. In order to allow the 2 new interlinked chromosomes to come apart, another bacterial enzyme is needed which is known as topoisomerase IV. This enzyme is structurally related to DNA gyrase and is coded for by the parC and parE genes. Topoisomerase IV allows for the 2 new inter-linked chromosomes to separate so that they can be segregated into 2 new daughter bacterial cells. Complete separation of bacterial cells Fluoroquinolones. First mechanism of action -- inhibition of DNA gyrase. Fluoroquinolones act by inhibiting the activity of both the DNA gyrase and the topoisomerase IV enzymes. For most gram negative bacteria, DNA gyrase is the primary fluoroquinolone target. Fluoroquinolones have been shown to bind specifically to the complex of DNA gyrase and DNA rather than to DNA gyrase alone. As a result of this binding, quinolones appear to stabilize the enzyme-DNA complexes which in turn results in breaks in the DNA that are fatal to the bacterium. A second mechanism of fluoroquinolone action is shown here. With some exceptions, topoisomerase IV is the primary target of fluoroquinolone action in most gram positive bacteria such as Staphylococci and Streptococci, with DNA gyrase being a secondary target. The separation of 2 new interlinked daughter strands of circular DNA is disrupted. The final result on the bacteria, however, is the same. Bacterial replication is disrupted and the bacterium breaks apart. The relative potency of different fluoroquinolone antibiotics (and thus their spectrum of activity) is dependent in part on their affinity for either DNA gyrase or topoisomerase IV or both. One of the most common mechanisms by which bacteria acquire resistance to fluoroquinolones is by spontaneously occurring mutations in chromosomal genes that alter the target enzymes -- DNA gyrase and topoisomerase IV or both. The frequency with which these spontaneous mutations occurs may be in the range of 10-6. The effect of mutations on the activity of an individual fluoroquinolone will vary depending on the number of mutations, the location of the mutations and which target enzyme is affected. If a mutation occurs (either in the gyrA or gyrB gene) that alters DNA gyrase and results in a reduced affinity of the fluoroquinolone antibiotic for this enzyme, the organism will become resistant. View animation to read more.
Views: 268083 Mechanisms in Medicine
FDA: Popular Antibiotics Have Serious Side Effects - Levaquin, Fluoroquinolone
 
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The FDA says certain antibiotics it approved have potentially permanent serious side effects. A lawsuit alleges that a former FDA commissioner suppressed this information. by Michael Tennant - http://www.thenewamerican.com/usnews/health-care/item/23202-fda-popular-antibiotics-have-serious-side-effects
Views: 237 VisionLiberty
Medical School - Antibiotics: Fluoroquinolones
 
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Discussion of the fluoroquinolone class of antibiotics. Remember it is learning made simple. Website: http://www.imedicalschool.org Follow us on twitter: https://twitter.com/iMedSchool Follow us on Facebook: https://goo.gl/75BdoZ iMedicalSchool is a channel dedicated to helping you understand complex medical topics in a simple manner. We are dedicated to making sure that you understand every topic presented. We are happy to answer questions and take suggestions. No matter if you are in medical school, nursing school or physician assistant school we are here to help you.
Views: 20299 iMedicalSchool
[13] Local Doctors Explain Risks Of Taking Levaquin ( Fluoroquinolone Toxicity )
 
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Website link: http://pittsburgh.cbslocal.com/2015/04/07/local-doctors-explain-risks-of-taking-levaquin/ Facebook page: https://www.facebook.com/CBSPittsburgh April 7, 2015 5:45 PM on CBS Pittsburgh PITTSBURGH (KDKA) – Some swear by them, others say they’re dangerous – if not deadly. KDKA-TV health editor Dr. Maria Simbra explains why some are calling for a closer look at a certain group of antibiotics. From time-to-time, Janice Olszewski’s mother, Mary, needs to take antibiotics for urinary tract infections. “She gets very weak, she gets sick. Sometimes, she’ll get disoriented,” Olszewski said. Her doctor prescribed a medicine called Levaquin. “He said it would help clear the infection, and we should get fairly quick results with it. It’s been a Godsend for us,” Olszewski said. “If it wouldn’t be for Levaquin, we’d have a hard time managing her health care. “I’d say 20-30 times a year, we give a prescription for levofloxacin,” Dr. Marc Itskowitz of Allegheny General Hospital’s Internal Medicine said. “We try to reserve it for patients who need a broader spectrum antibiotic, may have been exposed to other antibiotics and are still sick. It’s very effective in those patients.” Taking it by mouth works the same as taking it by IV. It also comes in an easy-to-swallow liquid. While it kept Janice’s mother out of the hospital, not everyone has had a good experience. Karen Paddock was taking out the garbage when she cut her leg on a broken dish in the trash bag. She got stitches, followed by infection of the skin – cellulitis. “At that point, they gave her the Levaquin antibiotics for the cellulitis,” Bob Paddock said. Six months later, she developed tendon troubles and couldn’t walk. “It was in 2003, and at that point, I’m not sure all the risks that are known today were known then,” Paddock said. After ten years of using a scooter around the house in chronic pain, at age 43, she committed suicide – four days shy of her 20th wedding anniversary. Her husband has strong hopes for all similar antibiotics. “That they either get taken off the market, or they get a whole lot harder for anybody to prescribe,” he said. Levaquin, generically known as levofloxacin, is in a class of drugs called fluoroquinolones. They work by attacking bacterial DNA, making the bacteria unable to multiply. Known risks include nerve problems and tendon rupture. Fluoroquinolones are not recommended for people taking steroids, people with a history of seizures, and people with certain heart rhythm abnormalities. Pharmaceutical watchdog Dr. Charles Bennett is trying to expand the warnings by bringing a citizen’s petition to the FDA. “I’ve been doing this work so long, that I think patients find me,” Dr. Bennett said. His focus is the rare complication of mitochondrial toxicity. You can think of mitochondria as your cells’ battery packs. Without them, your cells have no energy. He said if an event happens right after the medicine is given, that would be a reaction. He also has lab researchers who have been able to recreate symptoms in mice. “There’s a little bit of an art, rather than a science. There’s not a specific diagnostic test,” he said. He would like to expand the black box warning on Levaquin, or establish a process so that patients must sign that they understand the risks of the drug. “This would make Levaquin a little bit less attractive to use if it goes through as a black box warning,” Dr. Amesh Adalja, of the UPMC Center for Health Securit, said. This infectious disease specialist said the class of antibiotics does have a role to play, but shouldn’t be prescribed automatically. “Even if you’re prescribing penicillin, it’s something you have to do with each infection that you treat. You have to make sure is this the right bug that you’re treating, and is this the right drug that you’re using,” Dr. Adalja said. “For every patient that has been harmed by a medication, there are thousands that have been helped by it. And we don’t often hear from them,” Dr. Itskowitz said. “She’s had adverse reactions in the past to numerous drugs, so we’re always very alert to those types of reactions. And we felt the risks were minimal,” Olszewski said. Hearing from Olszewski, she’s thankful her mother had the option of Levaquin. “Within a couple of days, she starts to feel better,” she said.
Levaquin Tendonitis
 
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https://www.TendonitisExpert.com/levaquin-tendonitis.html Levaquin Tendonitis is NOT regular tendonitis. The Levaquin antibiotic, a member of the fluoroquinolone class of antibiotics (along with Cipro, Avelox, Levofloxacin, etc) attack a person's connective tissue structures and can even cause DNA damage. If you are suffering from Levaquin side effects, you MUST educate yourself about how Levaquin works and how to give your body it's best chance at being able to recover.
Views: 16919 TendonitisExpert
Antibiotic Body Damage Recovery (Levaquin Cipro Side Effects and How I Healed)
 
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It is my opinion only, that the damage these antibiotics are causing to people's bodies may be partially or fully due to the drug's destruction of crucially important healthy forms of bacteria in the gut. This, along with leaky gut which I believe is epidemic, may cause both a fungal version of yeast called candida to breach the barrier in the gut, and give the immune system a particularly difficult time managing it, as well as oxalate to also permeate the entire body causing a potential double-whammy that if addressed, may reverse the condition. Lots to be pissed off about with this situation. But one biggie is in how people are being told this condition is permanent. Although I believe it can be difficult to reverse, I believe it is entirely possible if approached from the above theoretical standpoint. That is how I approached it, and have had tremendous results. See my programs as well as the free info over at http://MaintenanceMotions.com. If you have some organic expeller-pressed coconut oil...or oil of your choice according to options available via Ayurvedic tradition...I'd give oil pulling a try, sticking with it for a solid few months. I have found it to be incredibly effective for joint/tendon issues, with dietary change, gut health with probiotics, and candida management to offer profound improvements. I need to consistently maintain the effort, but it's a part of my lifestyle regardless. Then I added some high quality ubiquinol to assist with mitochondrial damage, and energy production. http://FacelessFatloss.com My Over 40 program: http://Over40andRipped.com And Facebook: http://facebook.com/tim.ripped Love, Happiness, Health and Peace.........Tim .
Views: 46992 facelessfatloss
[1] Fluoroquinolone Toxicity: Medication Warning
 
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CBS Iowa Updated: Fri, Apr 03 2015, 10:29 PM EDT Her career is in insurance, but Patti Ireland's passion is photography. For years, Ireland would travel across the country photographing wild birds in their habitat. But a photography trip two years ago, would be her last. A trip to the doctor changed everything. After an asthma problem, her doctor gave her prednisone, a drug that's also known to weaken the immune system. As an extra precaution, she says her doctor then gave her a strong antibiotic called levofloxin, brand name Levaquin. It was a pre-emptive strike on any potential illness, not because she had symptoms. She says, "48 hours after I was given the first pill, I woke up with tremors, which you can hear in my voice and see in my hands. Ringing in my ears that sounds like living in a tent full of cicadas." Ireland wondered if the Levaquin pill was causing it. "I called the doctor and she said, 'Oh, no, it must be the prednisone. Keep taking it.'" She stopped taking the prednisone but took one more Levaquin pill. That was it. "8 days after stopping it," she says "I was in a hotel room in Florida on a photographic trip and I woke up in the middle of the night feeling like there wre hot pokers in my body. I couldn't walk. I had trouble breathing. I was panicking." Now two years later, the tremors are constant. Basic tasks like getting a drink of water are a challenge. There are no more photography hikes into the woods and her physical and cognitive issues forced her to retire early from her career. Dr. Julie Buchkina, MD, did not prescribe the Levaquin, but now treats Ireland's symptoms. She says, "It appears the symptoms she has experienced since then, are permanent." She goes on to say, "Ever since she took the Levaquin, she has struggled with new health conditions that she previously didn't have." There is a black box warning right now on Levaquin, the strictest warning a drug can have. But it warns of tendon issues like tendon ruptures and tendonitis, not the nerve and cognitive damage Patti is living with. The year after Patti took the two pills, in 2013, the FDA recommended warnings on the label and they are now posted to include the potential for nerve damage called peripheral neuropathy. The same report also points out the long-term damage to mitochondria cells, problems that could lead to diseases like Alzheimer's, Parkinsons and ALS. Dr. Buchina says, "Currently there is no official warning on Levaquin to warn abou the risk of increased damage to mitochondria, but that is something the FDA is looking into." Ireland doesn't blame the doctor who prescribed it. She says it was given to her in good faith. She also cannot sue the drug maker, as it was a generic version of Levaquin. She now just wants changes including regulation of this powerful antibiotic, adding "These drugs need to be regulated. They should only be used as they were designed, which is in life threatening situations where an infection isn't responding to any class of antibiotic." Read More at: http://cbs2iowa.com/news/features/top-stories/stories/Medication-Warning-110580.shtml
Fluoroquinolones Warning - Levaquin
 
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Tendon injuries and ruptures are being reported from fluoroquinolones such as Levaquin.
Views: 379 legallawhelp
Learn Fluoroquinolones Faster with Picmonic (NCLEX®, Nursing School)
 
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Learn Fluoroquinolones faster with the Picmonic Learning System! TRY PICMONIC FOR FREE ► https://www.picmonic.com/?utm_source=youtube&utm_medium=social&utm_term=1481129673&utm_content=video_link&utm_campaign=youtubenursingpicmonicwalkthroughs_2016 ————————————————— Picmonic turns the information you need to know in medical and nursing school into unforgettable images and stories that are scientifically proven to increase memory retention! Join over 125,000 medical and nursing students using Picmonic’s Visual Learning Community to study and learn more effectively in less time. Picmonic is research proven to increase test scores by 50% and long-term memory retention by 331%. Picmonic for Medicine has you covered for USMLE Step 1 and Step 2 CK, with subject including Pathology, Pharmacology, Microbiology, Biochemistry, Psychiatry, Anatomy, Physiology, Epidemiology, and more! Picmonic for Nursing has you covered for your classes and the NCLEX® with subjects including Fundamentals, Pharmacology, Med-Surg, Anatomy, Physiology, Pediatrics, Obstetrics, Psychiatric, and more! ————————————————— LET’S CONNECT! General Facebook ► https://www.facebook.com/picmonic Nursing Facebook ► https://www.facebook.com/picmonicfornursing Twitter ► https://twitter.com/picmonic Instagram ► https://www.instagram.com/picmonic/ Pinterest ► https://www.pinterest.com/picmonic/ LinkedIn ► https://www.linkedin.com/company/2703135 Google+ ► https://plus.google.com/+Picmonic/posts —————————————————
Views: 13705 PicmonicVideo
My Fluoroquinolone Story- Cipro and Levaquin poisoned me.
 
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Cipro and Levaquin literally poisoned my body and I want the world to know how dangerous these drugs are. This is my journey of recovery from the awful aide effects of these drugs.
Achilles' Tendon Tears and Fluoroquinolones
 
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In our video, we discussed how the antibiotic class of Fluoroquinolones can cause tendon tears in several areas of the body, especially the Achilles tendon. There are several types of Fluoroquinolones, including: ciprofloxacin (Cipro), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), and gemifloxacin (Factive). This class of antibiotics have often been used in the treatment of bronchitis, sinus infections, and urinary tract infections in the past. At this time, it has been recommended that the Fluoroquinolones class of antibiotics be used as a second or third line option for resistant bacterial infections due to the serious side effects. In my physical therapy practice, I've seen several cases of acute Achilles tendinopathy and complete Achilles tendon tears, from one week to six months, after taking a course of this type of antibiotic. This can occur in the highly active athletic population that is more prone to Achilles tendon problems and who typically assume Achilles tendon pain is related to their current training. The other high-risk group is more sedentary, less active individuals with poor tendon health and other co-morbidities such as diabetes. We've also seen these antibiotic side effects in tennis elbow and rotator cuff tendon problems. When initiating physical therapy with this population, you must take a very conservative approach in progressing the strengthening and stretching of the individual. In the cases of Achilles tendon tears and tendinopathies, occasionally we will provide heel lifts, ankle boots or orthotics. One of the difficulties in providing a proper diagnosis is noticing the causal relationship between taking the antibiotics and the resulting tendon pain or dysfunction. Often the patient doesn't link the two events and associates the pain with normal muscular skeletal pathology. In some cases, pain in the Achilles can also be related to a lumbar pathology or referred from a retro calcaneal bursitis, plantar fasciitis and / or ankle dysfunction. At my clinic, we guide patients through a McKenzie mechanical evaluation of the foot and ankle complex to rule out whether some of the Achilles pain is related to another structure in the foot and ankle complex. Upon completion of the evaluation, we hope to establish a movement or position that will increase a patient’s mobility and reduce their pain with certain movements and ultimately restore their ability to function. If you are unsure if you've taken this type of antibiotic, consulting with your pharmacy is a good first step. In cases where you suspect you may be having a side effect from this type of antibiotic, it is imperative that you discontinue any activity that produces pain and consult with a physician.
Critical Basics of Levaquin Tendonitis
 
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Levaquin Tendonitis is not the same thing as 'regular' tendonitis. Fluoroquinolones like levaquin, levofloxacin, cipro, ciprofloxacin, norfloxacin, avelox, moxifloxacin, etc, cause all sort of symptoms including tendon pain, muscle pain, muscle weakness, muscle spasms/twitches/cramps, joint pain, symptoms that look/feel like regular tendonitis symptoms. But tendonitis from Levaquin is an entirely different animal than regular tendinitis. Fluoroquinolone toxicity is one result. Nutritional depletion is another. Mitochondrial damage and DNA damage or worse results. If you took levaquin or cipro and have tendonitis symptoms, you also have nutritional depletion (definitely) and quite possibly also have connective tissue mitochondria damage, and worse than that, connective tissue DNA damage. Also, if you have tendon pain (your tendon is affected), you MAY also have damage to connective tissue around any other joint(s) in the body, to the connective tissue in/around organs (including the brain), and possibly to the connective tissue around nerves. Levaquin tendonitis is bad news, and isn't really tendonitis. Find out more at https://www.TendonitisExpert.com/levaquin-tendonitis.html
Views: 2639 TendonitisExpert
Fluoroquinolone Antibiotic Toxicity Victims Levaquin Cipro Avelox FDA Pharmaceutical Drugs
 
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Fluoroquinolone Antibiotic Toxicity Victims Levaquin Cipro Avelox FDA Pharmaceutical Drugs
Views: 175 FQ Europe
[7] Southland Firefighter Says Popular Antibiotic Poisoned His Body (Fluoroquinolone Toxicity)
 
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CBS Los Angeles March 4, 2015 11:16 PM losangeles.cbslocal.com/2015/03/04/southland-firefighter-says-popular-antibiotic-stripped-him-of-his-career/ A Southland firefighter wants to warn others about a prescription drug that he says poisoned him and stripped him of the ability to do what he loves. Chino resident Chris Jones was taking a powerful antibiotic called ciproflaxacin, more commonly known by the brand name “Cipro.” It’s taken by millions of Americans every year. Cipro belongs to a class of antibiotics called fluoroquinolones, which are so strong they can kill anthrax. They’re used to kill a wide variety of bacteria responsible for many common infections. Jones’ ordeal started in October with a bout of groin pain, which he thought was a hernia. His doctor suspected it was an infection and prescribed him Cipro, but Jones took the generic. Two days after starting the medication, Jones called his doctor about soreness he was feeling in his legs. The doctor said to keep taking the medication. Jones went to a specialist and told him about disturbing side effects patients were reporting online. He said the new doctor didn’t believe ciproflaxacin caused those problems: “He told me to stay off the Internet, and he wrote me another prescription.” A day after starting his third bottle, Jones starting feeling excruciating pain from his hips down: “I went on a walk with my dog and it felt like an explosion went off in my body.” Jones says he hasn’t been the same ever since. And no one missed the “old Chris” more than his twin brother, Jeremy: “We used to go to the gym together, hiking together.” They used to work at the same fire station, but Chris hasn’t worn his uniform for five months. That’s because he says he can’t climb ladders, can’t lift gurneys, and he can’t even lift his own children. “I was poisoned,” Chris Jones said. Some experts say fluoroquinolones are prescribed too freely for illnesses that could be treated with less powerful medications. “Doctors are not aware of the full range of toxicities that are associated with the quinolones,” said Charles Bennett, a professor of pharmacy at the University of South Carolina. Bennett has filed a citizen’s petition asking the federal Drug and Administration for broader warning for fluoroquinolones. He says Chris Jones is far from alone: “His story is typical of many of the stories I’ve read about and looked through the FDA files on.” The FDA has logged more than 4,500 reports of debilitating side effects linked to fluoroquinolones. Drug makers and the FDA are open about many of these drugs’ dangers, including damage to the tendons and nerves, which are listed on the label. But with up to 23 million prescriptions of fluoroquinolones being filled in a year, Jones believes they haven’t done a sufficient job of warning the public of the medications’ dangers. Jones says the FDA acknowledges that some side effects could be permanent: “I just don’t know if I’m going to get better or not. And no one can tell me.” The FDA told CBS2 it is continuing to monitor complaints and that petitions to update warning labels remain under consideration.
[8] Devastating side effects prompt local push to ban antibiotic ( Fluoroquinolone Toxicity )
 
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NBC Charlotte 6:09 a.m. EST February 25, 2015 http://www.wcnc.com/story/news/health/2015/02/24/devastating-side-effects-prompt-local-push-to-ban-antibiotic/23977183/ It is a commonly prescribed antibiotic-- doctors offer it for everything from urinary tract infections to sinus infections. But a local mom is pushing to get Levaquin off the shelves after she suffered devastating side effects. And a drug watchdog group is pushing the FDA for tougher warning labels. Shannon Myers is trying to slyly wrap his Valentine's day gift for wife Adrienne. The two are very much in love and very much a team– no matter what. "Every day you push through it, you push through it because you have to," Adrienne says. Adrienne endures grueling physical therapy several times a week; the 36-year-old mother of two struggles to walk. "It's very painful for me, just because my Achilles hurts really bad, so in order for me to not lose strength in my legs, I have to do this. I just have to bear the pain." It started last summer. Adrienne was diagnosed with a sinus infection; doctors prescribed Levaquin, the brand name for a drug called Levofloaxacin. A few days into the prescription she says, "I started having issues with my legs-- my legs hurt, they burn, felt like I walked up hill all day, my feet hurt, I had problems with my eyes, my vision started becoming kind of blurred." It took three months and four doctors to come up with a diagnosis. Dr. Ki Jung, Adrienne's neurologist, says the Levaquin caused tendinopathy and peripheral neuropathy. He says he helped rule other things out and worked on a timeline to figure out what happened. Jung says, "I told Adrienne, let's put a timeline to this and see where we are and then see if we can tease out any correlations; that's really where we were able to get to the notion that this was a Levaquin problem." "So basically the drug attacked her nerves and tendons?" "Correct, in terms of a side effect profile." Adrienne was shocked. "He said unfortunately you have nerve damage from taking Levaquin." Dr. Charles Bennett chairs a drug watchdog agency at the University of South Carolina. He was not at all surprised to hear Adrienne's story. "I'm not surprised. I've been working on this for years. This woman is a story that's replicated in city after city, case after case." He recently petitioned the FDA for new, what's called black box warnings for Levaquin, those are bold warnings meant to grab your attention. The FDA already required black box warnings in 2008, warning of possible tendon rupture and muscle weakness. And in 2013 the FDA required a label change warning of nerve damage. Bennett says the FDA's own stats show 1200 people have died and nearly 100,000 have suffered side effects from Levaquin or Levofloaxcin. "Thankfully it's not life threatening for me. I'm very fortunate that it has not been a life threatening thing for me, so I think about the positive and hopefully my nerves will regenerate themselves and become healthy again," Adrienne says. Her husband Shannon just wishes he could take away her pain. "It makes you wish, just like anybody you love, you could go back and do something about it. Like wish you had more time, researched more, maybe take it off her shoulders a little bit and put it on yours." NBC Charlotte reached out to Levaquin for a statement. They responded Tuesday evening: "LEVAQUIN® (levofloxacin) Tablets is part of an important class of anti-infective prescription medications that have been used for more than 20 years to treat infections, including those that may be serious or life threatening. When used according to the product labeling, LEVAQUIN® has been proven to have a favorable benefit-risk profile." The best advice: ask your doctor and your pharmacist to go over the possible side effects of this drug-- or any other for that matter, and if you have concerns, ask for an alternative.
NAD IV Therapy for Fluoroquinolone Toxicity Syndrome
 
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After taking an antibiotic called fluoroquinolone and experiencing severe medical complications due to toxicity, Case went searching for treatments that would give him relief. Case found hope in NAD+ and discovered that NAD+ helps your mitochondria regenerate. Hear Case's story and how he experienced positive benefits that helped him cope with the negative impact of fluoroquinolone toxicity syndrome. For more stories like Case's visit us at http://www.nadtreatmentcenter.com/about-us/testimonials/
Views: 2647 NAD Treatment Center
Adverse effects of fluoroquinolones [Levaquin, Cipro, Avelox]  Pt. 1
 
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http://en.wikipedia.org/wiki/Adverse_effects_of_fluoroquinolones
Views: 5081 mcinkyt
Cipro and Tendinitis
 
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cipro and other fluoroquinolone antibiotics have been associated with tendonitis and tendon rupture
Views: 12174 DrER.tv
Levaquin is toxic poison (Cipro & Avelox too!)
 
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Beware of ALL fluoroquinolone antibiotics! The 'cure' is often much, much worse than the disease with this toxic class of drugs. The FDA knows all about the damage these antibiotics are doing to the public, but chooses to look the other way. Protect yourself!
Views: 8721 CiproIsPoisonDotCom
I was Floxed - Beware of Levaquin!
 
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Beware of Levaquin - this is a powerful antibiotic. I was in the hospital for kidney stones and was given this stuff to fight off any infection. This stuff ended up fighting me! I haven't felt right since.
Views: 1674 uwtitanfan
Side Effects of Fluoroquinolones
 
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Which antibiotic should you try to avoid taking, if possible…next Side effects of fluoroquinolones far more disabling than other antibiotics, experts say Idelle Davidson writing in the Washington Post reported on the side effects of fluoroquinolones, noting that levofloxacin ranked third “in the number of serious adverse event reports submitted directly to the Food and Drug Administration in 2013,” while ciprofloxacin, another fluoroquinolone, ranked fifth, according to the Institute for Safe Medication Practices. Experts say that fluoroquinolones “can be far more disabling than other antibiotics” because of the life-altering nature of their side effects, which include tendon rupture, disabling peripheral neuropathy or permanent nerve damage to the arms and legs, eye disorders, psychiatric and nervous system disorders, seizures, ringing in the ears, and burning and tingling sensations. Comment: I have seen a number of tendon issues associated with these fluoroquinolone antibiotics.
Views: 1219 Nathan Wei
Cipro Vlog WARNING : levaquin antibiotics: how to heal
 
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TAMARIND DETOXES FLUOROIDE: https://en.wikipedia.org/wiki/Tamarind http://www.ncbi.nlm.nih.gov/pubmed/11840184 http://www.ncbi.nlm.nih.gov/pubmed/22096321 young man commits suicide from levaquin: https://www.facebook.com/WRTV6/posts/10153720158649092 hundreds of comments from people describing their lives impact on news story: https://www.facebook.com/tmj4/posts/10153751913648757 Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network: https://www.ncbi.nlm.nih.gov/pubmed/26955658 corrupt head of FDA being sued over Levaquin: http://www.naturalnews.com/053767_Margaret_Hamburg_FDA_commissioner_conspiracy_and_racketeering.html hundreds of adverse reactions stories: https://www.consumeraffairs.com/rx/cipro.html support for those who have been devastated by floroquinalones: https://www.facebook.com/groups/floxies/ how to recover from floroquinalones: https://www.linkedin.com/pulse/have-you-been-floxxed-drugs-what-do-jack-kruse stories of hope and recovery from cipro/levaquin/avelox https://floxiehope.com/2016/02/05/loss-of-faith-in-the-healthcare-system/ cure prostatis : http://www.prostatitis.org/doityourself.html
Views: 3308 taxivid
BEWARE OF CIPRO, LEVAQUIN & AVELOX!!!
 
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Fluoroquinolone antibiotics (Cipro, Levaquin, Avelox and a few others) are a horrifically destructive class of poisons marketed to the public as antibiotics by Bayer and Johnson & Johnson. They are capable of massive harm, disabling unsuspecting patients for life with as little as a few pills. Previously healthy and active individuals become bedridden, wheelchair-bound or requiring crutches or walkers--sometimes for life. Doctors will not tell you this, nor will pharmacists! DO YOUR RESEARCH! The FDA is not protecting us! Already harmed by Cipro or Avelox? Please email Bayer's CEO Phil Blake directly: philip.blake at bayer dot com or call him at his NJ office: 1-862-404-5018. This man needs to hear from his victims!
Views: 33342 CiproIsPoisonDotCom
Fluoroquinolone Antibiotic Toxicity Families Cipro Levaquin Avelox FDA Pharmaceutical Drugs
 
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National News Coverage: http://www.pbs.org/newshour/bb/health/jan-june11/antibiotics_06-16.html
Views: 3563 FQAntibioticToxicity
[4] Dangerous side effect of popular antibiotic ( Fluoroquinolone Toxicity )
 
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11:38 PM, Mar 26, 2015 WFTS TAMPA BAY A urinary tract infection sent Largo resident Nancy Garlow to a doctor last fall. He prescribed one of the popular antibiotics in a group known as fluoroquinolones. The pain hit on day five. Garlow claims she read the drug insert but only after severe side effects took over and she could barely walk. She said no one mentioned these pills carry a black box warning – the FDA's strongest – regarding "serious nerve damage" and debilitating pain. Seven months later, Galow says she remains too sick to return to work. In Sarasota, Dr. Susan Tannenbaum said she's spent the last 12 months putting her life back together. A bout of bronchitis led to a prescription for another popular fluoroquinolone, levofloxacin, whose brand name is Levaquin. By day seven she was unable to get out of bed. Dr. Tannenbaum describes being in the kind of pain that left her barely able to move and it lasted for months. Dr. Charles Bennett who heads up South Carolina's drug watchdog agency says he’s concerned about the number of people who’ve suffered devastating side effects. FDA documents show they've received 1,200 reported deaths related to Levaquin and its generic levofloxacin between 1997 and 2012. Dr. Bennett said only 1 percent of adverse effects are reported to the FDA. Last summer Dr. Bennett filed a petition with the FDA for stronger warnings about more of Levaquin's side effects, including those on the brain. The FDA upgraded its nerve damage warning in 2013 on all fluoroquinolones. Dr. Tennenbaum said she is proof it is not enough. We asked the FDA about the petition. They responded via email: "The FDA takes concerns raised about safety of approved drugs very seriously and we are considering the matters raised by the petition and giving it our careful attention." Johnson & Johnson, the makers of Levaquin, told us it monitors the safety of all of their medicines and incorporates new data into their labels so doctors and patients can make informed decisions. Here is the company’s statement in full. Statement from Janssen: At Janssen, our first priority is the well-being of the people who use our medicines. We are aware of the Citizen Petition and we are evaluating it. LEVAQUIN® (levofloxacin) is part of the important fluoroquinolone class of anti-infective prescription medications that have been used for more than 20 years to treat infections, including those that may be serious or life threatening. All medicines, including LEVAQUIN®, have both benefits and risks. We continually collect and monitor information on the safety and effectiveness of all our medicines, and, in cooperation with the US FDA and other health authorities, we incorporate new data into our product labels so doctors and patients can make informed decisions. Ever since it was first approved by the FDA in 1996, the LEVAQUIN® label has provided information to physicians on the risks and benefits associated with the medication, including warnings and precautions.
"But You Don't Look Sick": Fluoroquinolone Toxicity
 
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Fluoroquinolone Toxicity is an invisible illness. We share our stories to shine a spotlight on what invisible illness looks like. We are a non-profit charitable foundation dedicated to research, advocacy, and education about Fluoroquinolone Toxicity. Fluoroquinolone antibiotics such as Levaquin, Cipro, and Avelox are associated with severe and often permanent adverse reactions. They are meant for life threatening infections, yet they are often improperly prescribed for routine infections such as sinus infections, UTIs and even as preventative measures. Know the risks and ask for a safer alternative. It could just save your life.
Fluoroquinolone Toxicity
 
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48 News Reports in between September 2014 and August 2015 have aired sharing the push for more warnings of Fluoroquinolone Antibiotics. Several were aired multiple times in different cities throughout the United States & there are more news stories currently in the works.
Views: 8815 chris0712jo
The Real Cost of Fluoroquinolone Antibiotics
 
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We are a non-profit charitable foundation dedicated to research, advocacy, and education about Fluoroquinolone Toxicity. Fluoroquinolone antibiotics such as Levaquin, Cipro, and Avelox are associated with severe and often permanent adverse reactions. They are meant for life threatening infections, yet they are often improperly prescribed for routine infections such as sinus infections, UTIs and even as preventative measures. Know the risks and ask for a safer alternative. It could just save your life.
FDA is NOT protecting you from Cipro, Levaquin & Avelox
 
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Think the FDA is protecting you? Think again. When the FDA keeps secrets, people lose their lives.
Views: 5149 CiproIsPoisonDotCom
FDA Speech testifying on the adverse effects of Levaquin & other Fluoroquinolones
 
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This is dedicated to Hannah Chambers, Nurse Practitioner at CVS Minute Clinic the nurse who floxed me. May you educate yourself and stop harming people with your recklessness. Maybe one day I will forgive you but that day is not today. Probably not tomorrow either.
Views: 3171 Nicole Delaine
Shattered Lives: Destroyed By Fluoroquinolone Antibiotics
 
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.Quinolone Vigilance Foundation is a non-profit charitable foundation dedicated to research, advocacy, and education about Fluoroquinolone Toxicity. Fluoroquinolone antibiotics such as Levaquin, Cipro, and Avelox are associated with severe and often permanent adverse reactions. They are meant for life threatening infections, yet they are often improperly prescribed for routine infections such as sinus infections, UTIs and even as preventative measures. Know the risks and ask for a safer alternative. It could just save your life.
Levaquin kills again!
 
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Neither your doctor nor the FDA is protecting you from this terribly destructive & deadly class of antibiotics. If you value your life, steer clear of ALL fluoroquinolone antibiotics including Levaquin, Cipro & Avelox!
Views: 2472 CiproIsPoisonDotCom
The Dangers of Fluoroquinolones-Levaquin,Cipro, and others.
 
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This video gives a brief desription of the adverse reactions of fluroquinolone antibiotics.
Views: 11959 KelBel586
My Story, Levaquin Poisoning, Detox, & More...
 
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Many have asked about my struggles with Levaquin poisoning, what I've done to heal, what kind of detox I have been doing, and how it has helped. This journey has turned into more of an opportunity to help others on their way to wellness, and wholeness; and for that I am forever grateful! Please feel free to send questions so I can include them in my upcoming videos. Have a blessed day!
Views: 2429 Tonya Risser
The Dangers of Fluoroquinolones
 
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Antibiotics can be an absolute lifesaver and they are, easily, one of the most important scientific advancements of the 20th century. However, as with all scientific advancements, there have been some recent developments that take this important discovery too far. In drugs like Cipro and Levaquin, scientists have developed a group of antibiotics known as fluoroquinolones. The liberal use of this extremely potent, wide spectrum antibiotics poses a major threat to our microbiome.
Views: 15091 DavidPerlmutterMD
[3] Popular Antibiotic May Be Causing Permanent Damage ( Fluoroquinolone Toxicity )
 
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WSET-TV Mar 30, 2015 11:03 PM Lynchburg, VA - Popular antibiotics used to treat common infections may be causing permanent damage. Fluoroquinolones have been at the center of more than 2-thousand lawsuits in the past year. They are among the most commonly prescribed antibiotics. Levaquin and Cipro are the big ones, and are used to treat everything from anthrax to a simple sinus or urinary track infection. "The most common side effects are nausea, vomiting and diarrhea, which can happen with any antibiotics" said Stephanie Puckett, Director of Clinical Pharmacy Services at Centra. Yet unlike other antibiotics, Fluoroquinolones come with a special 'black box' warning. That's the FDA's strictest warning, alerting patients of the possible nerve and tendon damage the antibiotic can cause. "I would consider the Fluoroquinolones a very strong or potent class of antibiotics because they do cover a large variety of organisms" said Puckett. But patients around the country say these prescription drugs carry more serious side effects than are listed on the label, including psychological effects. They have banded together on the Facebook page "The Fluoroquinolone Wall of Pain", to push the FDA for stronger warnings. Group member Wayne Smith says he only took Levaquin for 3 days and suffered from "depression from hell, crying all day and night for no reason at all… Panic attacks, 24/7 anxiety that would not stop." Similarly Lana Kennedy says she was "in a state of extreme confusion & began experiencing severe panic attacks" after taking Cipro. Patients filed a citizen's petition asking the FDA to expand its warning on Fluoroquinolones. The new warning would include other reported side effects like damage to mitochondria in cells and psychological effects. The FDA says "they are considering the matters raised by the petition and giving it [their} careful attention."
[9] Popular antibiotics could cause permanent damage ( Fluoroquinolone Toxicity )
 
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ABC 10 News 6:12 AM, Nov 24, 2014 http://www.10news.com/news/investigations/patients-experts-popular-antibiotics-could-cause-permanent-damage-11242014 For Jenny Frank, it started with a small white pill she took nearly four years ago. "I was prescribed Levaquin for a strep infection," she said. "I can't compare myself to the person I was in December in 2010." Levaquin is one of the most commonly prescribed antibiotics on the market. Frank said it left her with persistent, painful and long-term side effects that affected her both physically and mentally. She recalls one moment as the scariest of her life. "About three weeks after I had stopped taking it, I started typing on the computer," Frank said. "When I looked at what I had written it wasn't even words." The science teacher said it was "gibberish." So, Frank deleted what she wrote and tried again. "Same thing… it was just random letters and numbers and things," she said. When asked what she was thinking, Frank said, "I can't even put a sentence together. Oh my god. Am I going to lose my job?" New warnings needed? Levaquin is in a class of antibiotics called fluoroquinolones. It is one of the most potent antibiotics approved by the Food and Drug Administration and is prescribed millions of times a year. Experts said that most Americans will take Levaquin in their lifetime. Team 10's investigative partners at ABC 15 in Phoenix spoke to researchers and patients across the country who believe that Levaquin carries more serious side effects than are listed on the label. They have filed a pair of citizen petitions this year asking the FDA to add new warnings to the label for a long list of psychiatric side effects ranging from depression to hallucinations and also something called "mitochondrial toxicity." In simple terms, researchers say that means it could alter and damage the body's cells. Dr. Charles Bennett helped write the citizen petitions filed with the FDA. Bennett, who says he has successfully petitioned the FDA before, is with the South Carolina College of Pharmacy and the Southern Network on Adverse Reactions (SONAR). He said he has been analyzing the effects of Levaquin and other fluoroquinolones for three years. Bennett said thousands of people have reported psychiatric side effects to the FDA. He also pointed to a 2013 FDA review of six different fluoroquinoles, including Levaquin, that raised the possibility of mitochondrial toxicity. Team 10 has also learned that full studies are underway at UC San Diego and the University of Rochester to look into these side effects. Experts: Overuse leads to added risk Frank is part of the fight to add new warnings to the label. "There's no reason why anyone should have to go through this if there are safer antibiotics that could be used," she said. "This should be a last resort. Not a first line of defense." It is a feeling shared by Dr. Ray Woosley, founder of CredibleMeds and a medication safety expert. He believes Levaquin and other fluoroquinolones are overprescribed. "The FDA put out a call two years ago that says don't overuse these drugs, but they continue to be overused," Woosley said. "It's like the wild west out there." Here is an example: During the anthrax mail attacks in 2001, victims were prescribed the fluoroquinolone Ciprofloxacin. "They are very potent antibiotics," Woosley said. "We can't take them off the market. We have got to have them available for whom they are lifesaving." But Woosley said that is also why these antibiotics should not be prescribed for things like sinus infections or prostatitis, like Tony Woods. Woods was prescribed Ciprofloxacin for a possible prostate infection two years ago. "There was no evidence I had an infection," said Woods, "He just wanted to treat me for what he thought was an infection." Woods took the pills for 19 days. "I started having extreme burning in my limbs, sensitivity to light, my eyes, my hearing, everything just felt rearranged," he said. "I couldn't smell or taste." The father of four was bedridden for months. "It's horrible," Woods said. "You go to bed thinking you are going to die … who's going to provide for my family?" Woods' attorney, John Fiske, said his firm, John Gomez Trial Attorneys, has been getting hundreds of calls a week from people who have taken these drugs. Fiske said the maker of Levaquin, Johnson & Johnson, faces a product liability lawsuit over side effects of the drug that allegedly caused peripheral neuropathy for one woman. The complaint was filed in August in the U.S. District Court for the Northern District of California. Fiske expects more to be filed against the makers of these drugs. "These are some of the most widely prescribed drugs in the world," said Fiske.
Levaquin and Avelox (Fluoroquinolones)
 
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Often simple ailments such a sinus infection or urinary tract infection may require an antibiotic. Unfortauntely, Fluoroquinolones such as Levequin and Avelox can damage collagen in muscle tissues, including the aorta of the heart which can lead to death.
Views: 34 lawyerworks
Levofloxacin Meaning
 
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Video shows what levofloxacin means. A broad-spectrum antibiotic having a fluoroquinolone structure.. Levofloxacin Meaning. How to pronounce, definition audio dictionary. How to say levofloxacin. Powered by MaryTTS, Wiktionary
Views: 1154 ADictionary
Tara - Levaquin Toxicity
 
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Hyperbaric Oxygen Therapy and Levaquin Toxicity. Please visit www.OxygenUnderPressure.com for more information.
Views: 629 HyperbaricHealing
Levaquin victims coming forward after news story
 
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Levaquin victims continue to come forward after news story airs. These terrible adverse reactions to fluoroquinolone antibiotics (Levaquin, Cipro, Avelox, etc) are NOT rare and neither your doctor nor the FDA is protecting you. If you value your life & your health, steer clear of ALL fluoroquinolone antibiotics.
Views: 4185 CiproIsPoisonDotCom
[11] Powerful Antibiotic Could Be A Prescription For Danger Pt. I (Fluoroquinolone Toxicity)
 
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February 13, 2015 10:51 PM CBS Miami http://miami.cbslocal.com/2015/02/13/powerful-antibiotic-could-be-a-prescription-for-danger/ Andrea Siani doesn’t get around her home like she used to, not since she was treated for pneumonia last winter. She was prescribed the generic version of Levaquin, a powerful antibiotic. “It was a prescription for 10 days. On the ninth day both my arms went numb. That night I woke up around midnight, and it felt like flames were coming out of my elbows,” said Siani. Thousands of patients have reported similar reactions to Levaquin, one of a powerful family of antibiotics known as Flouroquinlones. So just how powerful is this class of drug? Two of the prescribed uses are for anthrax and the plague. Levaquin has a black box warning from the Food and Drug Administrtation for increased risk of tendon ruptures, muscle weakness and impacts on the central nervous system. Dr. Marylee Worley is a professor at Nova Southeastern University’s College of Pharmacy. “A black box warning is the most serious warning that a medication can get before really being pulled from the market,” explained Worley. “It is powerful,” said Dr. Charles Bennett. He is one of the nation’s leading watchdogs for prescription drugs. He said the big problem with flouroquinolones is inappropriate use. “We are talking about going into the physicians office, having a little sniffle, walking out with an antibiotic and shortly after having these kinds of problems,” Bennett said. He has filed two citizen’s petition with the FDA seeking to expand the black box warning to include mitochondrial toxicity, meaning damage can occur within a patient’s cells. The second petition wants to highlight the potential for serious psychiatric events. Caroline Eagan was given Levaquin to treat a sinus infection. Eight years have passed and the former daycare provider has never been the same. “One day I can be okay, on focus. And another day I can’t even talk to anybody because they are not making sense. It sounds like they are not speaking English,” said Eagan. Levaquin is made by a subsidiary of Johnson and Johnson. In a statement, they said the antibiotic, “Has been used for more than 20-years to treat infections, including those that might be serious or life threatening. When used according to the product labeling, Levaquin has been proven to be a safe and effective medication.” Dr. Worley has a word of caution for people considering taking it. “We know this class of anitibiotics is being overly prescribed. If you start experiencing pain, especially around your ankle, call your doctor immediately,” advised Worley. Eagan regrets her doctor didn’t give her any warning. “You don’t be normal and then three days after taking a medication, and it was the only medication I was on, you can’t walk,” said Eagan. In a statement, an FDA spokesperson said the agency is reviewing the citizen’s petitions, adding they consider drug labels living documents so they can be updated, as new safety information becomes available.
Dangers Of Taking Ciprofloxacin
 
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A doctor that prescribes Ciprofloxacin didn't know that the very debilitating side effects would happen to him when he took it. I am making this post because I know 2 people that were recently prescribed Ciprofloxacin for their colds. DON'T TAKE IT. Both had very bad side affects. Fluoroquinolones can lead to arrhythmias. This is especially important if using levofloxacin or ciprofloxacin with amiodarone. You're not sick... You're being poisoned. Seek natural remedies and stay away from prescription meds whenever possible. Sometimes you can't avoid them, But research what you put in your body. Don't just blindly trust doctors. As you can see in this video. This doctor was also unaware of the dangers. I hope this post saves somebody's life. #4biddenknowledge
Ciprofloxacin Nursing Considerations, Side Effects, and Mechanism of Action Pharmacology for Nurses
 
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Grab our free cheatsheet covering the 50 most commonly prescribed medications right here: http://NRSNG.com/50meds Listen to all the episodes at: https://www.nrsng.com/medmaster-podcast/ View the blog post here: https://www.nrsng.com/ciprofloxacin-cipro/ Ciprofloxacin Generic Name: ciprofloxacin Trade Name: Cipro Indication urinary tract infections, gonorrhea, respiratory tract infections, bronchitis, pneumonia, skin and bone infections, infectious diarrhea, abdominal infections Action: inhibits bacterial DNA synthesis Therapeutic: Class anti-infectives Pharmacologic Class: Fluoroquinolone Nursing Considerations:  contraindicated in allergies  may cause QT prolongation, avoid use with other drugs that can cause QT prolongation  can cause seizures, arrythmias, pseudomembranous colitis, anaphalaxis, Stevens Johnson syndrome  may decrease effects of phenytoin  monitor renal panel  assess for infection, obtain cultures prior to therapy  monitor liver function tests
Fluoroquinolone Toxicity FQ D.C. Rally May 7-9, 2014 Testimonies (Jane)
 
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Personal testimonies from individuals harmed by the class of drugs (antibiotics) Fluoroquinolones. Washington D.C. Rally and Conference May 7-9 2014. Cipro, Levaquin. Avelox, Floxin. The damage and permanent adverse consequences to the human body from this class of drugs.
Views: 428 Lola Campagnuolo
Levaquin reaction  FDA failure  Google: "Death by Levaquin" for my website
 
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Video from a victim of Levaquin, visit: ww.fqvictims.org or www.fluoroquinolones.org Help us get on local or national media. Tens of Thousands of us are damaged by Levaquin, Cipro, Avelox and other quinolones.
Views: 24892 Robert Grozier