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Methylphenidate (Concerta/Ritalin) Induced Neurotoxicity

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The Study: http://link.springer.com/article/10.1007%2Fs12035-015-9219-x
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Text Comments (48)
Sonia Raheja (1 day ago)
The study that you shared is in prefrontal cortex if rats, while you may be right to project it directly to sapien brain, would you please share if you have come across any quality trials or case reports or any anecdotal evidence of this in humans. Thanks
Eagle Nebula (1 day ago)
Idk what to think or believe tbh cuz we often heard that ADHD is the most studied psychiatric disorder and medication have been used, developed and monitored to idk what extent for bout 50 years now or so and they say it's safe, besides what could ppl who have it do anyway, unless you work on something that doesn't require decent intellectual effort and many working hours you won't go far yet alone survive in modern society... Also how long exactly are we talking about on treatment? Edit: I just read the study's abstract and several points are worth mentioning I think: 1- the study was done on rats (although I'm aware of the genetic similarities we share) 2- it uses 2 mg/kg of body weight which is a lot more than the doses prescribed for many adhd treatments. 3- it concerns treatment since very young age, we can't conclude just from this that it'd have the same effects for ppl who started treating during adulthood.
Ocean Of Fun -KO (2 months ago)
what nootropic do you use personally
Tim Tagg (8 months ago)
7,777'th view :D
Endier (9 months ago)
But can u get high of of it
Kris Pullar (29 days ago)
Mercy Segen I agree I'm on 72mg of methylphenidate and it's not about the high it's about how to better your self with the medicines help
Mercy Segen (1 month ago)
Possibly yes. Ritalin affects people very differently. You might feel euphoric (high) or you might feel an increase in anxiety and your heart rate might get uncomfortably fast. However, getting high is NOT the aim of the drug for people with ADHD. I use Ritalin IR (20mg a day, about to start taking a 2nd dose of 10mg in a bit) and I do not get high from it. Ritalin works differently in people who have ADHD and people who do not. I don't feel high when I use it, I feel that I have more energy and that it's easier for me to concentrate. I don't suffer from any side effects other than a slightly increased heart rate every now and then. If you are taking Ritalin and constantly getting high off of it then the drug is not working the way that it should and you should consider asking your doctor for a decreased dose.
김베리 (4 months ago)
-Endier - yeah
Dual lands (1 year ago)
Dude stop the metaphores 😅
vfddcv (1 year ago)
What do you propose for adhd treatment then?
Eagle Nebula (1 day ago)
That's exactly the problem, we're kinda facing a dilemma, imo one solution would be taking the med for certain periods of time and then take a break by slowly reducing the intake so that the transition is smoother and the perceived difference isn't brutal and by not taking it during rest days like each weekend and holidays in cases you require the extras. So sad to have this disorder man espec if you work in already mentally high demanding jobs.
You're right and (2 months ago)
NZT
Konodus (3 months ago)
Weed
Pankaj Ahuja (1 year ago)
https://www.ncbi.nlm.nih.gov/m/pubmed/22805600/ then we have this too :) what a wonderful world
TheJeniferfisher (1 year ago)
Can you discuss Guanfacine and ADHD in kids or something along those lines? my 8 year old son takes this and I'm afraid of what he will have to try, if\when that stops working. Also, I really love your videos. Honesty and facts. It's sad that these two extremely important things are so hard to find these days. Thank you.
Kody Ryba (1 year ago)
wow, you have renewed my zest for knowledge! subbed xo (btw it helps that you r very handsome lol )
warefairsoda (1 year ago)
Agreed, assuming irreversible and permanent cation diode bridging between both neuronal nodes could occur and retain perfect dielectric isolation, which of course is impossible - even random cellular oxidation would nullify any charge gate over time.
jacob de villiers (1 year ago)
So you are saying negative feedback mechinisms make sure the dopamine levels reach equilibruim yet it will not do it once more off ritalin leading to chronically low dopamine levels ......wrong. But cool videos though.
Zak Khan (1 year ago)
Thank you for your two videos. For someone who uses Concerta, a methylphenidate based product, it is sad to know these effects occur. However, its difficult to stop the drug because of how difficult life is when your brain seems to work chemically different to others. Can I ask if you have any theories or thoughts on how those effects of methylphendiate could be mitigated against to some extent? Anything shared would definitely be welcomed!
LoneRBlackWolf (1 year ago)
I have a few questions... i have real bad ADHD and im taking Methylphenidate and it seems to help focus at work but im worried about whats going to happen later on, i need the concentration or else i will no longer be able to work and end up on the streets, is there other types of medication i could take that has reduced long term effects and still provide a solution for my concentration and when you say long term, how long do you mean? 1 yeah, 2 years or a period or 10 years? Does it affect everyone the same way?
Ásgeir Loftsson (1 year ago)
All true, is this explained for kids or the parents ?
Ásgeir Loftsson (1 year ago)
Sons of Apollo does methylphenidate rewire adults brain and is there a potential negative results in ceasing intake after 2+years of taking it
Sons of Apollo (1 year ago)
Anyone who is interested.
Cal (1 year ago)
Seems like he talks to both...he explains shit pretty well.
Chituga Khalifa (1 year ago)
I use to thought that all Methylphenidate drug have aphrodisiac
Ethan Coutts (1 year ago)
Watch the mood swings!
Augustine Quintero (1 year ago)
i have ADHD and the horse in the background isn't helping
Mercy Segen (1 month ago)
You sure you have ADHD or are you just making it for internet points? We're really not that easily distracted, that's more of a stereotype.
Alexander.G (2 months ago)
Augustine Quintero lol
0x (2 years ago)
How does one minimize the adverse effects of chronic use of methylphenidate? Holidays? I take it as prescribed, my psychiatrist insists that taking it as prescribed hold no danger.
Matthias Polard (2 years ago)
And we speek about a very studie drugs
Matthias Polard (2 years ago)
No no and no i am french ritalin specialist and no mph don't create this dramaticly dopaminergic effect at standard dosage
Pumpkin Pie (2 years ago)
nice expanation. I'm currently looking for a treatment like adderall or ritalin, but I've found none without some kind of neurotoxicity. it's for poor concentration, cognition, memory, motivation, confusion. in short, brain fog with a feeling of exhaustion, which is only worse with mental or physical exertion. probably myalgic encephalomyelitis. I feel like I'm out of options. know any good substitutes to help me feel sharp, driven, and alive just like adderall would?
Brian Pollard (2 years ago)
Pumpkin Pie try Asian ginseng. It isn't super powerful but it can have profound effects on some people. Make sure you take it correctly, also, get enough sleep. So many people get diagnosed as having ADHD and get put on meds because they only get like 5 hours of sleep a night. Surprise, they improve (albeit temporarily) from the amphetamine class stimulant so the doctor assumes he was correct. We live in a messed up world. I haven't been able to find anything really definitive on whether or not ADHD medications are unsafe long term in people with ADHD.
mindyourbusiness (2 years ago)
intraperitoneal injections of methylphenidate (2.0 mg/kg) - quite a dose and using an efficent route of administration.
yolo brent (2 years ago)
also could you compare concerta to adderall????? or levomethyphenidate to dexmethlphenidate?????
Concerta is basically the same as methylphenidate it's like comparing Adderall to Vyvanse.
yolo brent (2 years ago)
i really enjoy your videos ive researched stimulant medications for over 6 years now and when i watch your videos you break it down to exactly what ive read on various other websites i was curious if u could do these kinda reviews on vitamins such as fish oil or vitamin d ect... also i take lithium carbonate maybe u could explain how that effects the brain my doc said it promotes cell growth also ive noticed a big improvement in memory since i started taking it. awesome videos keep them coming.
James Brophy (2 years ago)
Long term usage is very bad and also what I consider to be a misuse of the medication. Short term usage like 3 months should also be accompanied by the patient learning about the neurobiological effects of exercise, since exercise causes the release of endogenous amphetamine, which can be a natural mechanism one uses to iron our cognitive defects after the MPH does its job.
agaragar21 (23 days ago)
Yes, intense exercise can help reduce some ADHD symptoms for a period of 45 minutes after the exercise. Knock yourself out ! What do you do when your knees disintegrate ?
Brian Pollard (2 years ago)
James Brophy you mean phenethylamine, not amphetamine? Because to my knowledge amphetamine is not naturally present in the body. There have been studies saying exercise helps with ADHD
Mike Hunt (2 years ago)
Can long term use of dexamphetamine lead to negative/ similar effects?
Sons of Apollo (2 years ago)
+Mike Hunt Absolutely, I made a video on my old channel about it. https://www.youtube.com/watch?v=aEwCWn4WquA
Kyuhyun (2 years ago)
I was waiting for this video!:D
Joseperez Jose2304 (1 year ago)
Jelle Willigenburg
Jelle Willigenburg (1 year ago)
+Magi Cruz it depends on what you take I guess I used to take medikinet 30 mg and that was the highest doses for that specific ADHD it also works for around 7~9 hours. I used it since I was 10 and now I have really bad sleeping problems I now take Ritalin which works les long but still severely screwed up my sleeping I now need to take sleeping pills but it's becoming better now but I've you stared using any ADHD drugs recently I recommend you just stop the long term effects are not worth it also I'm using it again because it makes my anxieties less of a burden but still just don't take it seriously also sorry for the bad English I'm Dutch btw
Kyuhyun (2 years ago)
+Sons of Apollo I will Jeje when I remember them... But is 25 mg a lot?
Sons of Apollo (2 years ago)
+Magi Cruz Your welcome! Let me know if you have any other questions that I may be able to answer.

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