Common Dosage for Cefuroxime Axetil
The drug dosage and form is decided by the physician based upon:
• Age and body weight of the patient
• Health status/medical condition of the patient
• Disease severity
• Reaction to the first dose
• History of allergy/drug reactions
A typical adult dosage for pharyngitis, tonsillitis, sinusitis, bronchitis, skin structure infections is 250 mg twice daily and for more severe infections, e.g., Pneumonia – 500 mg twice daily.
Cefuroxime Axetil tablets are not recommended for infants and children less than 12 years of age.
Cefuroxime Axetil Suspensions – The dose depends on the weight of the child. Your doctor or pharmacist will tell you exactly how many teaspoonful or 5 mL measures of the liquid suspension your child must take.
Precautions – When to Avoid Cefuroxime Axetil?
• Cefuroxime Axetil doesn’t work in case of viral infections (such as flu, common cold)). Unnecessary use of antibiotic must be avoided because it decreases its efficacy.
• Cefuroxime Axetil should be avoided in patients with previous allergic reactions to cefuroxime, cephalosporin, penicillin, or other drugs.
• Aspartame present in Cefuroxime Axetil suspension is a source of phenylalanine and therefore it should not be used in patients suffering from phenylketonuria.
• Cefuroxime Axetil should not be used in patients with a history of cephalosporin-associated hemolytic anaemia.
• The use of Cefuroxime Axetil should be avoided in patients suffering from gastrointestinal disease, particularly colitis.
• Cefuroxime Axetil should be avoided if you are having a urine test for sugar. False positive reactions may occur.
• Cefuroxime Axetil should be avoided if you are diabetic. CEFTIN Suspension contains sugar (about 3 g/5 mL).
• Cefuroxime Axetil should be avoided if you are pregnant or planning to become pregnant.
• Cefuroxime Axetil should be avoided if you are breastfeeding or planning to breastfeed. Cefuroxime is excreted in human breast milk.
Common side effects of cefuroxime Tablets
Diarrhea, nausea, vomiting, loose stools. Reports of abdominal pain have occurred.
• Clostridium Difficile-Associated Disease (CDAD) has been reported with use of many antibacterial agents including Cefuroxime Axetil.
• Transient increases of liver enzyme levels [ALT, AST, LDH].
• Headache and dizziness
• Allergic reactions – Rashes, itching, or shortness of breath may occur.
• As with other cephalosporins, there have been rare reports of drug fever.
Decreased hemoglobin, and very rarely a faster breakdown of red blood cells leading to a form of anemia (hemolytic anemia) with symptoms such as fatigue, shortness of breath and looking pale can occur.
Additionally, drowsiness, infections in vagina and transient increases in serum bilirubin, creatinine, alkaline phosphatase, and urea nitrogen van occur as side-effects with injectable forms of Cefuroxime Axetil.
Effects of Cefuroxime Axetil on Organs?
• Effects on liver have been reported. Symptoms of liver damage include –
o Jaundice (yellowing of the eyes and skin)
o Pain in the stomach
o Severe tiredness
o Dark urine
o Increased levels of liver enzymes
• In patients suffering from kidney diseases, the dosage of Cefuroxime Axetil should be decreased.